Disorders of phenylalanine tyrosine metabolism

Phenylalanine is an amino acid that needs to be absorbed through food. It is needed to make tyrosine, an important substance that makes the skin pigment melanin, the thyroid hormone thyroxine, and the messenger catecholamines. It is also degraded by the transformation into homogentisic acid.

The normal phenylalanine tyrosine pathway is as follows: phenylalanine> tyrosine> homogentisic acid> maleylacetoacetic acid> acetoacetic acid / fumaric acid The last two substances are then further modified in another metabolic process.

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