The most common side effects with novamine sulfone include nausea and vomiting and a slight red coloration of the urine. In addition, there may also be circulatory fluctuations. In addition, skin changes, confusion and consciousness cloudiness can very rarely occur. In case of a permanent intake of Novaminsulfon the analgesic, however, can cause organ damage, especially in the kidneys.
Novaminsulfone: Beware of allergic reactions
In rare cases, taking Novaminsulfone may cause a hypersensitivity reaction and subsequent shock. In the worst case, this side effect can have fatal consequences.
In existing pre-existing conditions such as bronchial asthma or hay fever can also be triggered by the intake of Novaminsulfon a seizure. This side effect occurs especially when Novaminsulfon is injected too quickly. Then it can also lead to a critical drop in blood pressure.
In comparison to other analgesics, however, it is positive to note that it is very well tolerated by the stomach. In addition, there is no addictive potential, as it exists for example in opioids.
Agranulocytosis as a serious side effect
Very rarely, the intake of novamine sulfone can damage the cell formation in the bone marrow (agranulocytosis). In the bone marrow the granulocytes - a subspecies of the leukocytes - are formed. Typical symptoms of agranulocytosis are fever and chills. Over time, the inflammation can spread to the entire body and can lead to sepsis.
If novaminsulfone is discontinued after the onset of symptoms and the injury is treated accordingly, the damage is usually reversible. However, if the analgesic is still taken, the mortality rate is about ten percent. The risk of agranulocytosis is particularly high with intravenous administration of novamine sulfone.
How often this serious side effect actually occurs, is controversial among scientists. While in some studies a probability of about 1: 1, 000, 000 is assumed, other studies estimate the risk at 1: 1, 439 significantly higher. Among other things, the different results are probably due to a different dose and a different period of use of the drug.
Novaminsulfone: banned in some countries
Due to its hazardous side effects, the use of Novaminsulfon in some countries, such as England, Japan, Denmark, Sweden or the US, is not allowed.
In Germany, however, the use is permitted. However, Novaminsulfon is mostly used only for short-term treatments and only for certain applications. Thus, the intake of Novaminsulfon by the Federal Institute for Drugs and Medical Devices is recommended only for the treatment of severe pain or in situations where other drugs do not suggest.
Finally, it should be noted that the absolute death rate of Novaminsulfone is 25 deaths per 100 million applications. Thus, the death rate is significantly lower than other analgesics such as acetylsalicylic acid (185 deaths) or diclofenac (592 deaths) (1). Patients taking Novaminsulfone should have a blood count taken on a regular basis and should contact the attending physician in case of an infection.
Source: (1) Andrade SE et al: Comparative safety evaluation of non-narcotic analgesics. J. Clin. Epidemiol. 51 (1998)