Novaminsulfone - Controversial Painkiller

Novaminsulfone is a non-opioid analgesic known as metamizole. Novaminsulfone has both an analgesic and a fever-lowering and slightly anti-inflammatory effect. The analgesic is usually used as a so-called reserve agent - it is administered when other medications fail. When taking the partially serious side effects of Novaminsulfon, the frequency of occurrence, however, is controversial to note.

This is how Novaminsulfone works

Non-opioid analgesics such as novamine sulfone do not exert their effect on the opioid receptors, unlike the opioid analgesics. Their effect comes about through the suppression of pain-inducing biochemical processes.

Within non-opioid analgesics, novalmine sulfone belongs to the group of non-acid analgesics. How exactly the active substances of this group, including Novalminsulfon, act, could not yet be clarified conclusively. However, it is believed that novamine sulfone inhibits the formation of prostaglandins, a group of tissue hormones. As messengers, they are significantly involved in the process of pain mediation.

Application and dosage of Novaminsulfon

The active ingredient novaminsulfone is used to treat moderate and severe pain. It can be used in both acute and chronic pain, such as tumor pain. Since Novaminsulfon also has an antipyretic effect, it can also be used in high fever - but only on condition that other drugs do not work.

Unlike most other non-opioid analgesics, Novaminsulfone also has an antispasmodic effect. Therefore, it may be used for pain relief in colic bile ducts or urinary tract.

Novaminsulfone is available in the form of drops, tablets and suppositories as well as a solution for injection. The dosage of Novaminsulfon depends on the existing symptoms and should always be clarified with the attending physician. In high fever or chronic pain, single doses of 500 milligrams or 1000 milligrams are recommended.

Depending on the method of administration, the effect of novaminsulfone starts about 30 to 60 minutes after administration. If Novaminsulfon taken orally and at the same time with food, this may have a delayed onset of action.

Novaminsulfone: Contraindications and Interactions

Novaminsulfon should not be taken if there is an incompatibility with the active substance. Novaminsulfon should not be used even if the production of the red blood pigment is disrupted. Likewise, the use of Novaminsulfon should be avoided during pregnancy and lactation and in infants under three months.

Children under the age of ten should only receive Novaminsulfone in consultation with a doctor and in the form of suppositories but not in the form of tablets. Suppositories of 300 milligrams should first be given to children from the age of four, suppositories of 1000 milligrams first to adolescents from the age of 15 years.

Likewise, should be dispensed with Novaminsulfon in certain diseases. These include acute hepatic porphyria (liver dysfunction) and a deficiency in the enzyme glucose-6-phosphate dehydrogenase. Persons who have low blood pressure should not be given intravenous Novaminsulfon, as this can cause a strong drop in blood pressure.

Interactions mainly occur with drugs that contain the active substance ciclosporin, since Novaminsulfon lowers the cyclosporin level. In addition, the efficacy of diuretics can be mitigated by Novaminsulfon. Likewise, concurrent use of novamine sulfone and the active ingredient chlorpromazine, which is used to treat psychotic disorders, can result in a significant decrease in body temperature.

Share with friends

Leave your comment