Paget's disease - therapy and diagnosis

How is the diagnosis made?

If there is suspicion of Paget's disease, an x-ray examination will usually confirm the diagnosis: the rapid, "sloppy" bone structure, the structural changes, thickening and deformations of the bone tissue are easily recognizable, possibly resulting in bone scintigraphy, which increases the metabolic activity in the body Bone shows.

Supportive blood and urine tests are carried out in which to detect more products of bone metabolism: alkaline phosphatase in the blood as an indication of increased bone structure, hydroxyproline in the urine as a sign of increased osteoclast activity.

Which therapy is there?

Although no cure is possible, often no treatment is necessary. The prognosis is very good. The extent of therapy depends on the symptoms:

  • Medicines: The overactive bone cells can be slowed down and bone formation promoted (calcitonin as a syringe or nasal spray, bisphosphonates as a syringe or tablet). In addition, medicines for pain relief can be used (analgesics, eg ibuprofen). Important is the adequate intake of vitamin D and calcium.
  • Orthopedic aids are used to compensate for bony bends and to relieve the supporting apparatus, for example as a corset or leg splint.
  • Operation: In severe cases, orthopedic surgical procedures may be necessary, such as bone fractures, joint destruction or nerve crushing.
  • Physiotherapy helps to balance the strain on bones and joints.
  • Alternative treatments: Acupuncture, autologous blood treatment, excretory therapy, enzyme therapy, manual medicine or bioresonance procedures may reduce pain and slow down the process of remodeling. However, scientific evidence of efficacy is lacking.

It is important to have regular medical check-ups to detect the transition to a malignant bone tumor at an early stage.

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