Clonidine helps with high blood pressure

The active ingredient clonidine is used to treat hypertension. In addition, the drug is also used to attenuate withdrawal symptoms in alcohol, drug or drug addiction. Ingestion can cause many side effects - including fatigue, dry mouth and headaches. We inform you in detail about effect, side effects and dosage of clonidine.

Effect of clonidine

Clonidine is used primarily in the treatment of high blood pressure (hypertension). The active ingredient in the body ensures that less adrenaline and noradrenaline are released. These two messengers ensure that blood pressure is boosted. When their concentration drops, the blood vessels relax and dilate and the heart has to work less vigorously. All this also causes the blood pressure to drop.

In addition to hypertension, clonidine can also be used as a support during anesthesia and to combat withdrawal symptoms. For example, the drug helps to reduce the withdrawal symptoms after alcohol, drug or opioid addiction.

Side effect of clonidine

There may be a number of side effects while taking Clonidine. The most common side effects include fatigue, drowsiness and dry mouth. Likewise, headaches, constipation, nausea and vomiting, impotence and a slowing of the heartbeat can be felt. Occasionally it can also cause skin reactions and itching.

On the other hand, side effects such as dizziness, sleep disorders, depression, mood swings, sensory disturbances, confusion and hallucinations are rather rare. Also rarely it comes to an increase in weight due to water retention.

To avoid further side effects, clonidine should never be discontinued abruptly, but slowly, step by step. Otherwise the so-called rebound phenomenon can occur. This can lead to an excessive reaction of clonidine, which can cause a very rapid and strong increase in blood pressure.

Dosage of clonidine

Clonidine can be taken either orally as a capsule or tablet, as well as injected intravenously, intramuscularly or subcutaneously. In addition, the active ingredient is available in different doses. In general, you should always start with the lowest possible dose and then slowly increase it if necessary.

Unless otherwise advised by the doctor, treatment is started at a dose of 0.075 milligrams. If necessary, the dose can then be further increased. However, an adjustment of the dosage should take place after about two to four weeks.


Under certain circumstances you should not take Clonidine. This is especially the case if you are allergic to the active ingredient. In addition, clonidine is also contraindicated in the following diseases or the patient requires careful medical supervision:

  • depressions
  • Low blood pressure
  • Renal dysfunction
  • Cardiac arrhythmia (AV block)
  • Fresh heart attack
  • Bradycardia with less than 50 beats per minute
  • polyneuropathy
  • Severe circulatory disorders
  • Severe disease of the coronary arteries
  • constipation

During pregnancy and lactation, the active ingredient should not be taken. Even children should not be treated with clonidine.


If clonidine is taken concomitantly with other medicines, interactions may occur. Therefore, always inform your doctor about which medications you are taking regularly. Among other things, interactions with the following drugs are known:

  • diuretics
  • hypnotics
  • neuroleptics
  • Tricyclic antidepressants
  • Vasodilatantien

In addition, the intake of drugs such as beta-blockers, which also influence the blood pressure, should be avoided. Otherwise it can lead to arrhythmia as well as a slowing of the heartbeat. Also, be careful not to consume alcohol with the active ingredient at the same time as it may increase the effect of clonidine.

Share with friends

Leave your comment